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MARRI LAXMAN REDDY INSTITUTE OF PHARMACY
(Approved by AICTE & PCI, New Delhi and Affiliated to JNTUH)
Dundigal - Gandimaisamma (V) &(M), Medchal (Dt), Hyderabad, Telangana - 500 043.
INDUSTRIAL
PHARMACY
LAB
MANUAL
1
About MLRIP
To be an educational Institute of par excellence and produce competent pharmacy professionals
to serve the community through research and the ever-increasing needs of Industry.
1. Imparting quality education and innovative research for various career opportunities.
2. Creating conducive academic environment to produce competent pharmacy professionals.
3. Indoctrination of students adorned with high human values and make them aware of their
responsibility as health care professionals.
PEO 1: To produce graduates with sound theoretical knowledge and technical skills required
for their career opportunities in various domains.
Program PEO 2: To incite the students towards research and to address the challenges with their innovative
Educational contributions for the benefit of the mankind.
Objectives PEO 3: To instill the essence of professionalism, ethical commitment to become a health
care professional with sound integrity and adherence to the core human values in the service
of the society.
PROGRAM OUTCOMES
1. Pharmacy Knowledge: Possess knowledge and comprehension of the core and basic knowledge associated
with the profession of pharmacy, including biomedical sciences; pharmaceutical sciences; behavioral, social,
and administrative pharmacy sciences; and manufacturing practices.
2. Planning Abilities: Demonstrate effective planning abilities including time management, resource
management, delegation skills and organizational skills. Develop and implement plans and organize work to
meet deadlines.
3. Problem analysis: Utilize the principles of scientific enquiry, thinking analytically, clearly and critically,
while solving problems and making decisions during daily practice. Find, analyze, evaluate and apply
information systematically and shall make defensible decisions.
4. Modern tool usage: Learn, select, and apply appropriate methods and procedures, resources, and modern
pharmacy-related computing tools with an understanding of the limitations.
5. Leadership skills: Understand and consider the human reaction to change, motivation issues, leadership and
team-building when planning changes required for fulfillment of practice, professional and societal
responsibilities. Assume participatory roles as responsible citizens or leadership roles when appropriate to
facilitate improvement in health and well-being.
6. Professional Identity: Understand, analyze and communicate the value of their professional roles in society
(e.g. health care professionals, promoters of health, educators, managers, employers, employees).
7. Pharmaceutical Ethics: Honour personal values and apply ethical principles in professional and social
contexts. Demonstrate behavior that recognizes cultural and personal variability in values, communication
and lifestyles. Use ethical frameworks; apply ethical principles while making decisions and take
responsibility for the outcomes associated with the decisions.
8. Communication: Communicate effectively with the pharmacy community and with society at large, such
as, being able to comprehend and write effective reports, make effective presentations and documentation,
and give and receive clear instructions.
9. The Pharmacist and society: Apply reasoning informed by the contextual knowledge to assess societal,
health, safety and legal issues and the consequent responsibilities relevant to the professional pharmacy
practice.
10. Environment and sustainability: Understand the impact of the professional pharmacy solutions in societal
and environmental contexts, and demonstrate the knowledge of, and need for sustainable development.
11. Life-long learning: Recognize the need for and have the preparation and ability to engage in independent
and life-long learning in the broadest context of technological change. Self-assess and use feedback
effectively from others to identify learning needs and to satisfy these needs on an ongoing basis.
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INDUSTRIAL PHARMACY LAB
List of Experiments:
1. Preformulation study for prepared granules
2. Preparation and evaluation of Paracetamol tablets
3. Preparation and evaluation of Aspirin tablets
4. Coating of tablets
5. Preparation and evaluation of Tetracycline capsules
6. Preparation of Calcium Gluconate injection
7. Preparation of Ascorbic Acid injection
8. Preparation of Paracetamol Syrup
9. Preparation of Eye drops
10. Preparation of Pellets by extrusion spheronization technique
11. Preparation of Creams (cold / vanishing cream)
12. Evaluation of Glass containers (As per IP)
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EXPERIMENT NO: 01
PREFORMULATION STUDY FOR PREPARED GRANULES
AIM: To perform different preformulation studies of prepared granules.
REQUIREMENTS: Measuring cylinder, Funnel, Sieves, Mortar & pestle, Spatula.
PRINCIPLE: Preformulation is defined as the phase of research and development in
which preformulation studies characterize physical and chemical properties of a drug molecule in
order to develop safe, effective and stable dosage form. The Objective of preformulation study is
to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile,
compatibility with the other ingredients and establish Physico-chemical parameter of new drug
substances. The major preformulation studies/parameters of granules are as follows:
1. Bulk density: It is defined as ratio of total mass of the powder to the bulk volume of
powder. It gives an idea about tablet porosity and its relationship with disintegration time
and hardness of a tablet. It is measured by pouring weighed powder into a measuring
cylinder and the volume is noted down. It is expressed in gm/ml and is given by
D=M/V
b o
Where,
M= Mass of powder,
V = Bulk volume of powder
o
2. Tapped density: It is defined as ratio of total mass of the powder to the tapped volume
of powder. Tapped volume is measured by tapping the powder to constant volume. It is
expressed in gm/ml and is given by:
D=M/V
t t
Where,
M= Mass of powder,
V = Tapped volume of powder
t
3. Angle of repose (Ɵ): It is the maximum angle possible between surface of pile of
powder and the horizontal plane, can be used to measure frictional forces in a powder.
-1
Ɵ= tan (h/r)
Where,
Ɵ= angle of repose
H height of the powder in cm, R is the radius of heap of powder
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